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Microbiota in Gastric Cancer by Gastric Mucosal Brushing
Sponsor: King Chulalongkorn Memorial Hospital
Summary
Many studies have shown a significant change of diversity and composition in gut microbiota across the gastric carcinogenesis process, particularly in patients with gastric cancer. However, there has been no analysis of gastric microbiota using the mucosal brushing technique, despite its favoring benefit in microbiota study. Therefore, this study aims to evaluate microbiota profile in patients with gastric cancer, compared to those without gastric cancer by using mucosal brush sampling. This will improve current knowledge of the potential role of the microbiome in patient gastric cancer as a future biomarker marker using brushing sampling.
Official title: Microbiota Diversity and Composition in Gastric Cancer by Gastric Mucosal Brushing: a Cross-sectional Case-control Study
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
40
Start Date
2024-02-01
Completion Date
2025-05-31
Last Updated
2024-05-07
Healthy Volunteers
Yes
Conditions
Interventions
Gastric mucosal brushing
Gastric mucosal brushing will be performed at body of stomach in control group and non-tumorous area of body in gastric cancer group. If gastric body area could not feasible (eg. tumor involvement), then gastric antrum and more proximal part of body will be sampling.
Gastric mucosal biopsy
Gastric mucosal biopsy will be performed at the area within 2 cm. from brushing site.
Locations (2)
King Chulalongkorn Memorial Hospital
Bangkok, Thailand
King Chulalongkorn memorial hospital
Bangkok, Thailand