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RECRUITING
NCT06326736
EARLY_PHASE1

Study of Neoantigen mRNA Vaccines in Patients With Resectable Pancreatic Cancer

Sponsor: Jinling Hospital, China

View on ClinicalTrials.gov

Summary

The purpose of this study is to evaluate the safety and efficacy of treating pancreatic cancer with surgery to remove cancerour tissue, followed by camrelizumab and a personalized cancer mRNA vaccines.

Official title: An Exploratory Clinical Study of Safety and Efficacy of Neoantigen mRNA Vaccines in the Treatment of Patients With Resectable Pancreatic Cancer

Key Details

Gender

All

Age Range

18 Years - 75 Years

Study Type

INTERVENTIONAL

Enrollment

12

Start Date

2024-04

Completion Date

2026-12

Last Updated

2024-03-22

Healthy Volunteers

No

Interventions

PROCEDURE

Surgery

Tumors of patients with pancreatic cancer must be radiographically resectable, and subjects with histologically confirmed resected ductal pancreatic adenocarcinoma with macroscopic complete resection (R0 and R1) will be selected for neoantigen vaccine creation.

DRUG

Camrelizumab

Camrelizumab will be administered 6 weeks post-tumor resection.

BIOLOGICAL

SJ-Neo006

SJ-Neo006 will be prepared as personalized tumor Vaccines and administered 9 weeks post-tumor resection (+/- 2 weeks).

DRUG

Gemcitabine+Abraxane

Gemcitabine+Abraxane regimen will be administered 21 weeks post-tumor resection.

Locations (1)

Wang Sizhen

Nanjing, Jiangsu, China