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Study of Neoantigen mRNA Vaccines in Patients With Resectable Pancreatic Cancer
Sponsor: Jinling Hospital, China
Summary
The purpose of this study is to evaluate the safety and efficacy of treating pancreatic cancer with surgery to remove cancerour tissue, followed by camrelizumab and a personalized cancer mRNA vaccines.
Official title: An Exploratory Clinical Study of Safety and Efficacy of Neoantigen mRNA Vaccines in the Treatment of Patients With Resectable Pancreatic Cancer
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
12
Start Date
2024-04
Completion Date
2026-12
Last Updated
2024-03-22
Healthy Volunteers
No
Conditions
Interventions
Surgery
Tumors of patients with pancreatic cancer must be radiographically resectable, and subjects with histologically confirmed resected ductal pancreatic adenocarcinoma with macroscopic complete resection (R0 and R1) will be selected for neoantigen vaccine creation.
Camrelizumab
Camrelizumab will be administered 6 weeks post-tumor resection.
SJ-Neo006
SJ-Neo006 will be prepared as personalized tumor Vaccines and administered 9 weeks post-tumor resection (+/- 2 weeks).
Gemcitabine+Abraxane
Gemcitabine+Abraxane regimen will be administered 21 weeks post-tumor resection.
Locations (1)
Wang Sizhen
Nanjing, Jiangsu, China