Clinical Research Directory

Inclusion Criteria: 1. Patient is male or female, 18 - 85 years old; 2. Patient is willing and able to give written informed consent; 3. Patient is able to comply with a prior medical examination; 4. Patient is or has been scheduled for a surgical procedure to correct epiphyso-metaphyseal and/or metaphyso-diaphyseal bone void in one of the following anatomical locations either after traumatic injury or elective surgical reconstruction: * Proximal humerus ▪ Distal radius * Distal femur ▪ Proximal tibia ▪ Distal tibia 5. Patient is willing and able to comply with the study procedures during surgery and the post-surgical follow up period, up to 12 months. Exclusion Criteria: 1. Patient has had an infection in the same extremity within last 24 months; 2. Patient has bone necrosis either after traumatic injury or elective surgical reconstruction at the surgical site; 3. Patient has cellulitis; 4. Patient has granuloma or non-curetted cyst; 5. Patient has a current or previous diagnosis of osteomyelitis; 6. Patient has a clinically significant degenerative bone disease; 7. Patient has an history of uncontrolled diabetes; 8. Patient is alcoholic and/or heavy smoker (\> 20 cigarettes per day); 9. Patient has a congenital or acquired immunodeficiency; 10. Patient has severe bone loss (≥ 40cm3); 11. Patient is on long-term steroidal therapy or treatment acting on the calcium or phosphorus metabolism; 12. Patient is or has been scheduled for surgery that would involve intra-articular implantation of the study device; 13. Patient who has or had an uncontained bone void (cavity) created as a result of trauma injury or surgically created; 14. Patient was exposed to any radiation (e.g. X-Rays, handling of radiolabelled materials) other than the normal background radiation within the 12 months before the screening visit; 15. Patient is pregnant or breastfeeding; 16. Patient who is an employee at the study site; 17. Patient is known to be non-compliant with medical treatment or follow-up 18. Patient has any significant or unstable medical/psychiatric condition that, in the opinion of the Investigator, would interfere with their ability to participate in the study; 19. Patient is currently enrolled or planning to enrol in another clinical study or treatment with another investigational drug/device that may interfere with the assessments, visits or outcomes of this study.