Clinical Research Directory
Browse clinical research sites, groups, and studies.
Opioid Sparing Anesthesia Care for Pediatric Patients Having Tonsil Surgery
Sponsor: Boston Children's Hospital
Summary
This is a prospective, randomized, controlled, non-inferiority study of patients undergoing tonsil surgeries at Boston Children's Hospital Waltham. The overall aim is to evaluate the efficacy of an opioid anesthetic plan (morphine, ketorolac, and acetaminophen versus an opioid sparing anesthetic plan (dexmedetomidine, ketorolac and acetaminophen) for perioperative analgesia and recovery time in patients undergoing tonsillectomies and tonsillotomies at Boston Children's Hospital Waltham. Secondary measures include rescue opioids administered in post-anesthesia care unit (PACU), re-operation secondary to bleeding, emergence delirium, post-operative nausea and vomiting, intraoperative hemodynamics, intraoperative vasopressor administration, and length of procedure.
Official title: Opioid Sparing Anesthesia Care for Pediatric Patients Having Tonsil Surgery; a Randomized, Controlled, Non-inferiority Study
Key Details
Gender
All
Age Range
3 Years - 17 Years
Study Type
INTERVENTIONAL
Enrollment
58
Start Date
2024-05-09
Completion Date
2026-04-01
Last Updated
2026-01-07
Healthy Volunteers
No
Conditions
Interventions
Dexmedetomidine
Dexmedetomidine (1mcg/kg bolus given intravenously at induction of anesthesia
Acetaminophen
Acetaminophen (12.5mg/kg with a maximum dose of 1 gram given intravenously at induction of anesthesia).
Ketorolac
Ketorolac 0.5mg/kg with a max dose of 30mg intravenously at the end of surgery.
Morphine
Morphine (0.1mg/kg given intravenously at induction of anesthesia)
Locations (1)
Boston Children's Hospital
Waltham, Massachusetts, United States