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Dexmedetomidine Infusion Dose Versus Rapid Bolus Dose Before Tracheal Intubation.
Sponsor: Kasr El Aini Hospital
Summary
Dexmedetomidine bolus dose may provide similar or less hemodynamic changes (less bradycardia and less hypertension) than infusion dose during induction of anaesthesia and tracheal intubation.
Official title: Effect of Dexmedetomidine Infusion Dose Versus Rapid Bolus Dose on Hemodynamic Changes During Laryngoscopy and Tracheal Intubation in Adults. A Randomized Comparative Study.
Key Details
Gender
All
Age Range
18 Years - 50 Years
Study Type
INTERVENTIONAL
Enrollment
70
Start Date
2024-04-01
Completion Date
2024-09-20
Last Updated
2026-06-16
Healthy Volunteers
Yes
Conditions
Interventions
Dexmedetomidine infusion
patients will receive Dexmedetomidine infusion dose of 1 mcg/kg over 10 min before induction.
Dexmedetomidine bolus
patients will receive Dexmedetomidine bolus dose of 0.3 mcg/kg over 60 seconds.
Atropine Sulfate
If heart rate falls below 45 bpm, rescue dose (500 mcg) of atropine will be given.
Ephedrine
If mean blood pressure decreases below 50 mmHg, boluses of 10 mg ephedrine will be given
Propofol
Propofol 20 mg boluses till loss of contact
Locations (1)
Cairo University Hospitals
Giza, Giza Governorate, Egypt