Inclusion Criteria:
2\. Are willing to comply with all study related procedures and assessments. 3. Are ambulatory as defined by ability to complete functional performance testing.
4\. Radiographic evidence of Kellgren-Lawrence grade II-IV osteoarthritis in one or both knees.
5\. Scores 4-10 on the Numerical Rating Scale (NRS) for pain. 6. Stable dose of screening/baseline medications for at least 2 months prior to the anticipated date of study drug dosing.
Exclusion Criteria:
1. Females who are nursing, pregnant or planning to become pregnant during the duration of study drug dosing.
2. Subjects who do not have the capacity to consent themselves.
3. Subjects who are unable to tolerate oral medication.
4. Subjects having previously undergone any of the following treatments in the stated time window:
1. Surgery on the Study Knee in the past 6 months.
2. Partial or complete joint replacement in the study knee. Partial or complete joint replacement in the contralateral knee is acceptable if the surgery was performed at least 6 months prior to enrollment and the operative knee is asymptomatic.
3. Patients who have undergone arthroscopic surgery (including microfracture and meniscectomy) on the Study Knee in the last 2 years prior to the Screening visit or are anticipated to have arthroscopic surgery on either knee at any time during the study period.
4. Steroid injection, including extended-release corticosteroid (e.g., Zilretta) within the last 5 months.
5. Biologic (platelet-rich plasma, bone marrow, adipose tissue/cells) or hyaluronic acid injection into the Study Knee in the past 6 months.
5. Subjects with any of the following drug/medication statuses:
1. Currently taking Losartan.
2. Currently taking Warfarin or related anticoagulant.
3. Opioid analgesics taken in the past 8 weeks and are not willing to discontinue these medications through the duration of the study.
4. Drugs that induce significant cellular stress and are not willing to discontinue these medications through the duration of the study, including alkylating agents, anthracyclines, platins, other chemotherapy drugs.
6. Subjects with any of the following disease statuses:
1. Significant liver disease (i.e. greater than or equal to 2x the upper limit of normal bilirubin levels).
2. Significant renal disease (eGFR of \<60 ml/min/1.73m2) .
3. History of other formally diagnosed joint diseases including osteonecrosis, acromegaly, Paget's disease, Ehlers-Danlos Syndrome, Gaucher's disease, Cushing's syndrome, Stickler's syndrome, joint infection, hemophilia, hemochromatosis, or neuropathic arthropathy of any cause.
4. Any active systemic autoimmune disease with musculoskeletal involvement or any history of system inflammatory arthritis.
5. Patients with type 1 or 2 diabetes (HbA1c\>6.5%) and/or taking medications that affect insulin levels, including: Metformin (within the last week), Glucocorticoids (within the last month), Acarbose (within the last week).
7. Subjects unable to safely practically undergo an MRI (BMI \> 40 kg/m2) or size exceeding limits of MRI equipment, implanted metal in study knee near joint surface, incompatible implant/device, severe claustrophobia.
8. Subjects that have any medical condition, including laboratory findings and findings in the medical history or in the pre-study assessments that constitutes a risk or contraindication for participation in the study or that could interfere with the study objectives, conduct or evaluation or prevent the patient from fully participating in all aspects of the study.
