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RECRUITING
NCT06328543
NA

Itch Sensation Induced by Multiple Applications of Pruritogens (temporal Summation)

Sponsor: Aalborg University

View on ClinicalTrials.gov

Summary

In This experiment, the investigators would like to design a new itch model based on the temporal summation of pruritic stimuli. The hypothesis behind this study (temporal summation) is that two overlapped applications of pruritogens will result in a higher itch sensation compared with a single application.

Official title: Repetitive Applications of Pruritogens and Effects of a Cutaneous-induced Pain Stimulation on Nonhistaminergic Itch Perception

Key Details

Gender

All

Age Range

18 Years - 60 Years

Study Type

INTERVENTIONAL

Enrollment

26

Start Date

2024-11-01

Completion Date

2026-12-31

Last Updated

2024-11-22

Healthy Volunteers

Yes

Interventions

OTHER

Histamine

Histaminergic itch will be evoked by a 1% histamine solution. A droplet of histamine solution will be placed on the predetermined area on the forearm, and the SPT lancet will be pierced through the histamine.

OTHER

Cowhage

25 spicules will be inserted in the center of the predefined skin area on the mandibular area. The spicules will be gently rubbed for 15-20 seconds in circular motion to facilitate epidermal penetration.

Locations (1)

Aalborg University

Aalborg, Aalborg, Denmark