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Inpatient Monitoring of Unfractionated Heparin
Sponsor: Vanderbilt University Medical Center
Summary
Unfractionated heparin (UFH) is the most widely used intravenous (IV) anticoagulant for treating and preventing thromboembolic disease (e.g., blood clots ). UFH must be closely monitored and adjusted in the hospital. There are two assays used to monitor UFH: 1) the activated partial thromboplastin time (PTT) and 2) the chromogenic anti-factor Xa assay (anti-Xa). This study aims to compare PTT and anti-Xa methods for monitoring UFH in a pragmatic, randomized controlled trial to determine which helps patients reach a therapeutic anticoagulation range faster.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
2000
Start Date
2024-06-26
Completion Date
2026-07
Last Updated
2026-04-02
Healthy Volunteers
No
Conditions
Interventions
PTT protocol
Patients will be monitored using the nurse-managed PTT protocol.
anti-Xa protocol
Patients will be monitored using the pharmacy-managed anti-Xa protocol.
Locations (1)
Vanderbilt University Medical Center
Nashville, Tennessee, United States