Clinical Research Directory

Inclusion Criteria: 1. History of diabetes mellitus; 2. Persistent pain and/or abnormal sensation in the extremities (at least in both lower limbs), decreased bilateral or unilateral ankle reflexes, decreased vibratory sensation (weaker in the medial ankle than in the medial tibial condyle), and decreased nerve conduction velocity on the affected side, and TCSS score \>5; 3. 18 years ≤ age ≤ 80 years; 4. Gender is not limited; 5. Those who have the ability of independent daily life and can cooperate to complete all the examinations; 6. Those who are conscious without serious mental diseases and cognitive disorders, and those who do not have serious cardiac, cerebral, hepatic, renal and other internal diseases; 7. Voluntary participation and signing of informed consent. Exclusion Criteria: 1. Those with peripheral neuropathy, ulcers and gangrene of the limbs caused by various other reasons (e.g. hypothyroidism, alcohol, drugs, heredity, etc.), or those with a history of skin ulcers or lesions that do not heal easily; 2. Women who are in preparation for pregnancy, during pregnancy or breastfeeding; 3. Those with acute complications such as combined diabetic ketoacidosis, lactic acidosis, severe infections, etc.; 4. Those who suffer from serious liver or kidney damage or serious cardiovascular and cerebrovascular diseases (angina pectoris, myocardial infarction, multiple cerebral infarctions, cerebral haemorrhage, etc.); 5. Those who have scars or pigmentation on the skin of the testing site, which will affect the accuracy of the test; 6. Those who are participating in other acupuncture or drug clinical trials.