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Imaging in Moyamoya Disease - Study to Investigate Different Imaging Technologies for a Better Understanding of Various Imaging Techniques to Evaluate Cerebral Hemodynamics, Disease-activity and Possibly the Etiology in Moyamoya Patients
Sponsor: University Hospital Tuebingen
Summary
Aim of this study is to improve patient care in Moyamoya Patients by improving Imaging technologies and aiming to identify factors involved in disease progression. Main tasks are: * Analysis of CO2-triggered BOLD fMRI for analysis of cerebral hemodynamics in comparison to H2 15O PET/CT * Analysis of longitudinal changes of contrast enhancement in vessel-wall imaging and correlation of disease activity with biosampling * Definition of a standardized recommendation for pre- and postoperative imaging of Moyamoya patients
Official title: IMAGINE - Imaging in Moyamoya Disease
Key Details
Gender
All
Age Range
18 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
50
Start Date
2024-07-01
Completion Date
2027-11-30
Last Updated
2024-09-26
Healthy Volunteers
Yes
Conditions
Interventions
MRI
Patients will get special MRI sequences (CO2-triggered BOLD MRI, Vessel-wall imaging, resting state BOLD MRI) to identify cerebral vasoreactivity and disease activity.
H2 15O PET/CT
Patients will get H2 15O PET/CT with acetazolamide challenge to define the cerebral vasoreserve for comparison with fMRI Images
Biosampling
Patients do get a venous puncture for blood analysis on circulating endothelial cells and virus PCR analysis
Locations (1)
University of Tuebingen, Neurosurgery
Tübingen, Baden-Wurttemberg, Germany