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Gut Oxalate Absorption in Calcium Oxalate Stone Disease
Sponsor: University of Alabama at Birmingham
Summary
The goal of this clinical trial study is to test if patients with idiopathic calcium oxalate kidney stones have an increased absorption of dietary oxalate, which would lead to increased urinary excretion of oxalate. The study will recruit adult patients with a history of calcium oxalate kidney stones and healthy volunteers without kidney stones. Participants will * ingest fixed diets containing low and moderately high amounts of oxalate for 5 days at a time * ingest a soluble form of oxalate and sugar preparations to test gut permeability * collect urine, blood, stool and breath sample during the fixed diets and the soluble oxalate test
Official title: Gastrointestinal Oxalate Absorption in Calcium Oxalate Stone Disease
Key Details
Gender
All
Age Range
18 Years - 70 Years
Study Type
INTERVENTIONAL
Enrollment
80
Start Date
2024-04-17
Completion Date
2031-12-31
Last Updated
2025-05-13
Healthy Volunteers
Yes
Conditions
Interventions
Low-oxalate diet
4 days of fixed eucaloric diet with low oxalate (\<60 mg/day), normal calcium content (600-1000 mg/day)
High-oxalate diet
4 days of fixed eucaloric diet with moderately high oxalate (250-300 mg/day), normal calcium content (600-1000 mg/day)
soluble oxalate gut absorption test
Oral ingestion of 13C2-oxalate and sucralose.
Locations (2)
University of Alabama at Birmingham
Birmingham, Alabama, United States
UTSW
Dallas, Texas, United States