Clinical Research Directory

Inclusion Criteria: * Informed Consent signed by the subject * Age ≥ 18 years * Willingness to sign informed consent and to participate in the study * Single tooth gap or extended edentulous space in the lower or posterior jaw including a pontic site with a soft tissue deficiency. * Tooth gap of ≥ 8 mm. * Presence of natural or artificial opposing dentition * Sufficient vertical interocclusal space of an implant restoration (7mm) * Bounded by natural and periodontally stable teeth * Treatment plan must include tooth replacement with an implant or tooth-supported fixed dental prosthesis. Exclusion Criteria: * Any physical or mental disorder that would interfere with the ability to perform adequate oral hygiene or the capability of providing written informed consent and compliance with the protocol * Severe bruxism, clenching habits, or presence of oro-facial pain * Uncontrolled diabetes mellitus (HbA1c \>7.0) * Clinically significant concomitant disease states (e.g., renal failure, hepatic dysfunction, cardiovascular disease, etc.) * Any active oral or systemic acute infections * Currently receiving chemo- or radiotherapy or a history of radiotherapy in the head and neck area * Severe hematologic disorders * Any other diseases or medications that may compromise normal wound healing * Pregnancy or nursing mother * Contraindications and limitations of the MD as described in the instructions for use: during pregnancy or lactation, children, presence of acute infection in the surgical area, patients with known sensitivity to porcine material or collagen allergies. * Vulnerable subjects * Known or suspected non-compliance * Drug or alcohol abuse * Inability to follow the procedures of the investigation, e.g. due to language problems, psychological disorders, dementia, etc. * Participation in another investigation with an investigational drug or another MD within the 30 days preceding and during the present investigation, * Enrolment of the PI, his/her family members, employees and other dependent persons