Clinical Research Directory

Inclusion Criteria: \- All patients with anterior circulation acute ischemic stroke planned to undergo endovascular thrombectomy will be screened for recruitment. Exclusion Criteria: * Admission core body temperature \<35°C. * Known contraindications to hypothermia, including hemodynamically unstable patients, new/symptomatic arrhythmia, hematological dyscrasias that affect thrombosis (cryoglobulinemia, sickle cell disease, serum cold agglutinins), or vasospastic disorders such as Raynaud's or thrombo-angiitis obliterans. * Skin lesions not allowing secure application of the cooling cap. * Unable to participate in follow-up at 3 months (e.g., resides outside of Alberta).