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RECRUITING
NCT06336174

Cognitive Decline and Underlying Mechanisms in Symptomatic Intracranial Artery Stenosis Patients: A Cohort Study

Sponsor: Anhui Medical University

View on ClinicalTrials.gov

Summary

The purpose of this study is to explore the mechanism of cognitive impairment in patients with symptomatic intracranial atherosclerotic stenosis (ICAS), and further plans to explore the impact of different treatment options on cognitive function in symptomatic ICAS patients.

Official title: Cognitive Decline and Underlying Mechanisms in Symptomatic Intracranial Atherosclerotic Stenosis Patients: A Multicenter Cohort Study

Key Details

Gender

All

Age Range

18 Years - 80 Years

Study Type

OBSERVATIONAL

Enrollment

100

Start Date

2022-11-01

Completion Date

2026-12-31

Last Updated

2025-11-17

Healthy Volunteers

No

Interventions

DRUG

Aspirin Tablet, Clopidogrel Bisulfate Tablets and Atorvastatin

All patients received standard medical management, including dual antiplatelet therapy (aspirin and clopidogrel) for three months with aspirin or clopidogrel monotherapy thereafter and high-dose statin, and treatment of hypertension to guideline targets.

PROCEDURE

Endovascular therapy,Aspirin Tablet, Clopidogrel Bisulfate Tablets and Atorvastatin

All patients underwent endovascular therapy and received standard medical management after surgery, including dual antiplatelet therapy (aspirin and clopidogrel) for three months with aspirin or clopidogrel monotherapy thereafter and high-dose statin, and treatment of hypertension to guideline targets.

Locations (1)

Anhui Medical University

Hefei, Anhui, China