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Antibacterial Tactics Based on Presepsin Level in Thoracic Aorta Surgery Patients
Sponsor: Petrovsky National Research Centre of Surgery
Summary
According to the literature, presepsin was recommended not only as an effective indicator in the diagnosis of sepsis in intensive care units, but also as a reliable prognostic marker of postoperative inflammatory processes in cardiac surgery. Previous study carried out in Petrovsky NRCS related to biomarkers in cardiac surgery and presepsin in particular showed good sensitivity in infection complications prognosis.
Official title: Changes in Antibacterial Therapy Based on Perioperative Dynamics of Presepsin During Reconstructive Thoracic Aorta Surgery
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
50
Start Date
2024-01-23
Completion Date
2027-02-15
Last Updated
2026-01-29
Healthy Volunteers
No
Conditions
Interventions
Ampicillin-sulbactam
If a patient meets dual criteria (presepsin \> 519,5 pg/ml at the end of surgery and the absence of presepsin increase after 6 hours after the end of surgery) then switching to ampicillin/sulbactam 3 g every 6 hours at least 72 h after the surgery is done.
Locations (1)
Petrovsky Research National Centre of Surgery (Petrovsky NRCS)
Moscow, Moscow, Russia