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Comparing Single Dose and Multiple Dose of Dexamethasone Post TKA
Sponsor: Thammasat University Hospital
Summary
The goal of this clinical trial is to investigate the efficacy of single dose and double dose of dexamethasone after primary total knee replacement. The main question\[s\] it aims to answer \[is/are\]: Does 24 hours-interval of double dose of dexamethasone have better analgesic effect than single dose and 12 hours interval of double dose of dexamethasone after primary total joint replacement? Researchers will compare double dose of dexamethasone group to see if \[insert effects\]. Participants will \[describe the main tasks participants will be asked to do, interventions they'll be given and use bullets if it is more than 2 items\].
Official title: Efficacy of Intravenous Dexamethasone Injection Given 12 and 24 Hours for Pain After Total Knee Arthroplasty: A Prospective Randomized Clinical Trial
Key Details
Gender
All
Age Range
50 Years - 85 Years
Study Type
INTERVENTIONAL
Enrollment
120
Start Date
2022-03-23
Completion Date
2025-10-31
Last Updated
2025-04-09
Healthy Volunteers
No
Conditions
Interventions
Dexamethasone before surgery
Dexamethasone 0.15 mg/kg IV before surgery
Dexamethasone before and 12 hours after surgery
Dexamethasone 0.15 mg/kg IV before surgery Dexamethasone 0.15 mg/kg IV at 12 hours post operation
Dexamethasone before and 24 hours after surgery
Dexamethasone 0.15 mg/kg IV before surgery Dexamethasone 0.15 mg/kg IV at 24 hours post operation
Locations (1)
Thammasat University Hospital
Khlong Luang, Changwat Pathum Thani, Thailand