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Neurofilament Light Chain And Voice Acoustic Analyses In Dementia Diagnosis
Sponsor: Monash University
Summary
This cohort study aims to determine if a blood test can aid with diagnosing dementia in anyone presenting with cognitive complaints to a single healthcare network. The investigators will measure levels of a brain protein, Neurofilament light chain (Nfl), and assess changes in language using speech tests. Participants will have a single blood test and speech test, and will be followed up at 12-months to complete questionnaires and cognitive scales over the phone. The speech test will also be completed again at 12-months. Individuals at risk of a Fronto-temporal dementia syndrome will be eligible to complete optional genetic testing involving an 'at home' saliva sample.
Official title: A Blood Test for Dementia? A Cohort Study to Assess the Diagnostic Utility of Plasma Neurofilament Light Chain Protein in All-cause Dementia
Key Details
Gender
All
Age Range
Any - Any
Study Type
OBSERVATIONAL
Enrollment
1000
Start Date
2021-08-01
Completion Date
2027-12
Last Updated
2025-05-30
Healthy Volunteers
No
Conditions
Interventions
Venepuncture
A single blood draw at the time of presentation to clinic or whilst an inpatient.
Locations (2)
Box Hill Hospital
Box Hill, Victoria, Australia
Wantirna Health
Wantirna, Victoria, Australia