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Early Onset Colorectal Cancer Detection
Sponsor: City of Hope Medical Center
Summary
Colorectal cancer (CRC) once predominantly affected older individuals, but in recent years has witnessed a progressive increase in incidence among young adults. Once rare, early-onset colorectal cancer (EOCRC, that is, a CRC diagnosed before the age of 50) now constitutes 10-15% of all newly diagnosed CRC cases and it stands as the first cause of cancer-related death in young men and the second for young women. This study aims to detect EOCRC with a non-invasive test, using a blood-based molecular assay based on microRNA (ribonucleic acid)
Official title: Development and Validation fo an Exosome-Based and Machine Learning Powered Liquid Biopsy for the Detection of Early-Onset Colorectal Cancer
Key Details
Gender
All
Age Range
18 Years - 50 Years
Study Type
OBSERVATIONAL
Enrollment
400
Start Date
2023-04-15
Completion Date
2026-06-18
Last Updated
2026-01-28
Healthy Volunteers
Yes
Conditions
Interventions
ENCODE
A panel of microRNA, both cell-free and exosomes, whose expression level is tested from plasma samples from patients with early onset colorectal cancer and non-disease controls.
Locations (13)
City of Hope Medical Center
Duarte, California, United States
IRCCS San Raffaele
Milan, Italy
Kawasaki University
Kawasaki, Japan
Mie University
Mie, Japan
National Cancer Center Hospital
Tokyo, Japan
Tokyo Medical and Dental University
Tokyo, Japan
Yamagata University
Yamagata, Japan
Barcelona University
Barcelona, Spain
Colorectal Surgery, Vall d'Hebron University Hospital, Universitat Autonoma de Barcelona UAB
Barcelona, Spain
Surgery Department, Hospital del Mar, Barcelona, Spain
Barcelona, Spain
Salamanca Biomedical Research Institute
Madrid, Spain
University of Salamanca-SACYL-CSIC, Salamanca, Spain
Salamanca, Spain
University of La Laguna
San Cristóbal de La Laguna, Spain