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Study On the Expression Level and Clinical Significance of VISTA in Patients With Vascular Cognitive Impairment
Sponsor: First Affiliated Hospital of Harbin Medical University
Summary
1\. Explore the expression level of immune checkpoint VISTA in peripheral blood and cerebrospinal fluid of patients with cardiovascular risk factors; 2. Discuss the correlation between different risk factors (mainly hypertension, diabetes, smoking, hyperlipidemia, hyperhomocysteinemia, etc.) and the expression level of immune checkpoint VISTA in peripheral blood and cerebrospinal fluid of patients with cerebrovascular diseases and immune-inflammatory related diseases of the nervous system; 3. Explore the correlation between different immune inflammatory factors (IL1, IL6, IL10, INFγ, TNFα) and the expression level of immune checkpoint VISTA in peripheral blood and cerebrospinal fluid of patients; 4. Track and explore the dynamic changes of immune checkpoint VISTA in peripheral blood and cerebrospinal fluid of patients with cardiovascular risk factors in 3 months, 1 year, 3 years, and 5 years.
Key Details
Gender
All
Age Range
50 Years - 80 Years
Study Type
OBSERVATIONAL
Enrollment
400
Start Date
2023-03-01
Completion Date
2028-11
Last Updated
2024-04-02
Healthy Volunteers
No
Conditions
Interventions
Neuropsychological testing
The primary outcomes were Mini-Mental State Examination and Montreal Cognitive Assessment scores for screening of cognitive decline, which are recommended by NINDS-AIREN. The secondary outcomes included the performance in five cognition domains: (1) verbal memory, Hopkins Verbal Learning Test ; (2) visual-spatial ability, Clock Drawing test; (3) executive function, Trail Making test (TMT) (B time); (4) attention, TMT (A time); and (5) language tests, Boston Naming test2 (BNT-2)
Locations (1)
First Affiliated Hospital of Harbin Medical University
Harbin, Heilongjiang, China