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ACTIVE NOT RECRUITING
NCT06342986
PHASE1

Intraperitoneal FT536 in Recurrent Ovarian, Fallopian Tube, and Primary Peritoneal Cancer

Sponsor: Masonic Cancer Center, University of Minnesota

View on ClinicalTrials.gov

Summary

This is a single center Phase I clinical trial of FT536 administered intraperitoneally (IP) 3 times a week for one week for the treatment of recurrent gynecologic cancers. A short course of outpatient lymphodepleting chemotherapy is given prior to the first dose of FT536 to promote adoptive transfer.

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

3

Start Date

2024-07-11

Completion Date

2027-06-30

Last Updated

2026-04-02

Healthy Volunteers

No

Interventions

DRUG

FT536

FT536 is an allogeneic natural killer (NK)-cell immunotherapy produced from a clonal master humaninduced pluripotent stem cell (iPSC) line.

DRUG

Fludarabine

Fludarabine 25 mg/m2 IV given on day -5. Given consecutively with CY.

DRUG

CY

CY 300 mg/m2 IV given on day -4. Given consecutively with Fludarabine.

Locations (1)

University of Minnesota Masonic Cancer Center

Minneapolis, Minnesota, United States