Clinical Research Directory

Inclusion Criteria: * Patients aged ≥ 70 years * Histological diagnosis of squamous cell or undifferentiated HNC in stage III-IV AJCC ed VIII (si-nonasal, nasopharynx, oral cavity, oropharynx, unknown primary with HPV pos, larynx and hy-popharynx) and candidated to curative non surgical treatment (radiotherapy alone, Chemora-diation with platinum salts; radiation+cetuximab) * Evaluable disease accordingly to RECIST criteria 1.1 * Willing of sign a written informed consent * Adequate organ function Exclusion Criteria: Patient with cancer in other sites than HN \< than 2 years except for prostate cancer cT1-2, Gleason 3+3, NIMBC, initial Non Melanoma Skin Cancer, in situ cervical cancer) * PS ECOG 3-4 * Patients who received systemic treatments in the past for other primary tumors