Clinical Research Directory

Inclusion Criteria: 1. Patients with healthy systemic condition. 2. Adult patients (18 years old and older). 3. Patients with stage lll periodontitis, having one isolated intrabony defect with probing depth \>6mm, clinical attachment level\> 6mm and at least 4 mm intrabony component involving predominantly the interproximal area of the affected tooth. 4. Patients with full mouth plaque score\<20%. 5. Patients with full mouth bleeding score\<20%. 6. Compliance with good oral hygiene. 7. Patients accept 6-months follow-up period (cooperative patients). 8. Patients provide an informed consent. Exclusion Criteria: 1. Ongoing drug therapy that might have an impact on the clinical signs and symptoms of periodontitis. 2. One wall intrabony defect. 3. Defects that involve the buccal and lingual sites. 4. Smokers ˃ 10 cigarettes / day. 5. Pregnant and lactating females.