Clinical Research Directory

Inclusion Criteria: 1. Age 40-90 years inclusively. 2. Per CT of the head, (one of the following): Unilateral convexity CSDH measuring at least 10 mm in thickness OR Bilateral CSDH if only one side is considered for treatment and the contralateral side is asymptomatic and \< 5 mm in thickness. 3. CSDH at least 2/3 isodense or hypodense, verified on axial CT slice used to measure the thickness of the qualifying CSDH. 4. Qualifying baseline head CT performed within the 7 days prior to randomization. 5. Able to undergo assigned treatment within 72 hours after randomization. 6. Patient or legally authorized representative agrees to be randomized, and provides written informed consent and Health Insurance Portability and Accountability Act (HIPAA) authorization. Exclusion Criteria: 1. Secondary cause apart from trauma for the qualifying SDH, such as an underlying vascular abnormality or tumor. 2. Tentorial or interhemispheric SDH. 3. Secondary to CSDH, MRC of 0, 1, 2, or 3 in any muscle group contralateral to the side of the CSDH 4. 4. Pre CSDH mRS of 5 or higher. 5. Secondary to CSDH, patient is unable to complete TUG (i.e.,TUG \> 120 seconds, unable to walk, or tries TUG but quits in ≤ 120 seconds). Note: This criterion does not apply if the patient does not complete TUG for reason other than CSDH. 6. Secondary to CSDH, ASR of 0, 1, or 2. 7. Emergent surgical evacuation such as open craniotomy, burr hole drainage, or Subdural Evacuating Port System (SEPS) is required for the patient. 8. Unable to withhold all antiplatelet agents or OACs for the first 7 days after randomization. 9. Indication that withdrawal of care will be implemented for the qualifying SDH. 10. Prior surgical treatment for CSDH if the surgery is less than 30 days prior to randomization. 11. On tranexamic acid. 12. Platelet count of \<100,000 per microliter refractory to transfusion. 13. Coagulopathy that cannot be corrected to an INR of ≤1.5. 14. Known contraindications to angiography. 15. Known intolerance to occlusion procedures. 16. Known vascular anatomy (small artery size) or blood flow (high vascular resistance peripheral to the feeding arteries) that precludes catheter placement or embolic agent (Embosphere Microspheres or CONTOUR particles) injection. 17. Known presence of collateral vessel pathways potentially endangering normal territories or cranial nerves during embolization. 18. Known large diameter arteriovenous shunt, i.e., where the blood does not pass through an arterial/capillary/venous transition but directly from an artery to a vein or presence of patent extra-to-intracranial anastomoses (where study embolization devices could pass directly into the internal carotid artery, vertebral artery, or intracranial vasculature) that cannot be addressed with coil embolization. 19. Patient has a known active systemic infection or sepsis. 20. Patient is pregnant, planning to become pregnant, or lactating. 21. Life expectancy of less than 6 months due to comorbid terminal conditions. 22. Concurrent participation in another research protocol for investigation of an experimental therapy. 23. Known or suspected to not be able to comply with the study protocol. 24. No measurable deficit secondary to the CSDH on the Timed Up and Go \[TUG\], Aphasia Severity Rating \[ASR\], or MRC. At baseline, a measurable deficit on the TUG is defined as: time \>10 seconds. At baseline, a measurable deficit on the ASR is defined as: a score\<4. At baseline, a measurable deficit on the MRC is defined as: a score \< 5 in any muscle group contralateral to the site of the CSDH.