Clinical Research Directory
Browse clinical research sites, groups, and studies.
Biomarker Identification and Nutritional Intervention of Primary Sarcopenia Based on Gut-muscle Axis
Sponsor: Peking Union Medical College Hospital
Summary
The loss of skeletal muscle mass and function usually occurs with aging, known as primary sarcopenia. Sarcopenia has a prevalence of 11.6% among the elderly population in China and is closely associated with increased risks of falls, disability, and mortality. Currently, there is a lack of definition criteria for sarcopenia based on biomarkers. The Gut-Muscle Axis hypothesis suggests a complex interplay between gut microbiota and skeletal muscle. Nutritional intervention targeting the gut microbiota potentially plays a significant role in muscle regeneration. Therefore, this study aims to explore the effects of symbiotic and whey protein on muscle, gut microbiota, and clinical outcomes among sarcopenia patients, to provide a reference for further diagnosis and treatment of sarcopenia.
Key Details
Gender
All
Age Range
65 Years - Any
Study Type
INTERVENTIONAL
Enrollment
120
Start Date
2024-04
Completion Date
2026-01
Last Updated
2024-04-22
Healthy Volunteers
No
Conditions
Interventions
symbiotic
The intervention is made up of multiple probiotics and prebiotics (20g/d) and dietary pattern modification.
whey protein
The intervention is made up of whey protein supplements (20g/d) and dietary pattern modification.
symbiotic placebo
The intervention is made up of maltodextrin (20g/d) and dietary pattern modification.
whey protein placebo
The intervention is made up of maltodextrin (20g/d) and dietary pattern modification.
Locations (1)
Peking Union Medical College Hospital
Beijing, Beijing Municipality, China