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Optimizing Pulsatility During Cardiopulmonary Bypass to Reduce Acute Kidney Injury
Sponsor: University of Colorado, Denver
Summary
The objective is to determine the effectiveness of pulsatile flow during cardiopulmonary bypass to reduce the incidence of acute kidney injury after cardiac surgery. Investigators will also evaluate the safety and impact of pulsatile flow on clinical outcomes compared to non-pulsatile flow during cardiopulmonary bypass.
Official title: Optimizing Pulsatility During Cardiopulmonary Bypass to Reduce Acute Kidney Injury: Randomized Controlled Trial
Key Details
Gender
All
Age Range
18 Years - 85 Years
Study Type
INTERVENTIONAL
Enrollment
1100
Start Date
2025-05-19
Completion Date
2028-10
Last Updated
2025-05-21
Healthy Volunteers
No
Interventions
Non-pulsatile blood flow
Non-pulsatile blood flow generated by constant centrifugal pump flow rate during cardiopulmonary bypass
Pulsatile blood flow
Pulsatile blood flow generated by variable centrifugal pump flow rate during cardiopulmonary bypass
Locations (1)
University of Colorado Hospital
Aurora, Colorado, United States