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NOT YET RECRUITING
NCT06351215
PHASE3

PO Methadone Ortho Outpatient

Sponsor: Keck School of Medicine of USC

View on ClinicalTrials.gov

Summary

The goal of this clinical trial is to learn if oral methadone given before surgery works to minimize post-operative pain and opioid usage. The main questions it aims to answer are: Does oral methadone improve post-operative pain scores as compared to standard treatment? Does oral methadone lead to reduced use of post-operative and post-discharge opioid usage as compared to the current standard treatment? Researchers will compare oral methadone to a placebo (a look-alike substance that contains no drug) to assess the questions above. Participants will: Receive either oral methadone or a look-alike placebo before surgery Receive standard intraoperative and immediate post-operative pain control at the anesthesiologist's discretion Be asked about their pain levels in the recovery area Keep a diary of pain and opioid usage over the first 2 days after surgery

Official title: Use of Single-Dose Oral Methadone for Pain Management in Outpatient Arthroscopic Hip and Knee Procedures

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

100

Start Date

2025-05-01

Completion Date

2025-12-15

Last Updated

2025-03-05

Healthy Volunteers

No

Interventions

DRUG

Methadone group

5mg PO methadone for participants \<50kg or 10mg PO methadone for participants \>50kg

DRUG

Placebo

sugar pill that is identical look-alike to study drug

Locations (1)

USC Healthcare Consultation 3

Los Angeles, California, United States