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The Relationship Between Controlling Risk Factors and Cerebral Haemodynamics in Lacunar Stroke
Sponsor: University of Leicester
Summary
The goal of this observational study is to look at differences in brain blood flow before and after management of risk factors such as high blood pressure and diabetes in patients with lacunar stroke. Participants will be asked to undergo a simple brain blood flow assessment at their initial appointment, whereby they will be asked to sit and stand twice. The patients will then be asked for a follow-up assessment 4 weeks after, identical to the first. This will allow us to look at any changes in brain blood flow from before management of risk factors and 4 weeks after management of risk factors.
Official title: Understanding the Relationship Between Controlling Risk Factors and Cerebral Haemodynamic Changes in Lacunar Stroke, and Its Interaction With Ageing
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
75
Start Date
2024-05-02
Completion Date
2026-03
Last Updated
2025-03-24
Healthy Volunteers
No
Conditions
Interventions
Transcranial Doppler Ultrasonography (TCD) during sit-stand manoeuvres
TCD will be used to measure the cerebral blood flow in the middle and posterior cerebral arteries. This will be done at rest and during two sit-stand manoeuvres, whereby the participant will be asked to stand (from a seated position) and stay standing for 1 minute. The participant will then be given time to recover before repeating the manoeuvre. This will occur at the first visit and the follow-up visit 4 weeks after.
Locations (1)
University Hospitals of Leicester NHS Trust
Leicester, Leicestershire, United Kingdom