Clinical Research Directory

Inclusion Criteria: * Surgical indication to radical cystectomy with diagnosis of muscle invasive bladder cancer (any N, any M), BCG (Bacillus Calmette-Guerin)-unresponsive non-muscle invasive bladder cancer or extensive non-muscle invasive bladder cancer that cannot be treated with endoscopic surgery alone; * Willingness to participate by signing written informed consent. Exclusion Criteria: * Age \< 18 years; * Pregnant or lactating women; * Participation in another study with nutritional supplements within the 30 days preceding and during the present study * Known hypersensitivity or allergy to components of immunonutrition or standard high-calorie high-protein oral nutritional supplement; * Need for artificial nutrition support due to totally compromised spontaneous food intake; * Diarrhoea with suspected malabsorption syndrome; * Inability to consume oral supplements as a consequence of pre-existing disease (e.g. dysphagia) or other factors (e.g. language barrier, psychological disorders, absence of a home caregiver in dependent or elderly patients); * Kidney failure with need for renal replacement therapy; * Type 1 diabetes mellitus; * Type 2 diabetes mellitus requiring insulin therapy and/or inadequate glycaemic control (glycosylated haemoglobin ≥7% and/or fasting plasma glucose ≥150 mg/dL); * Inability to give an informed consent.