Clinical Research Directory

Inclusion Criteria: 1. ≥18 years old at the time of onset; 2. AIH simplified score ≥6 and/or AIH revised score ≥10; 3. Liver biopsy was performed and consistent with the pathological diagnosis of AIH; 4. Patents were treatment naive or who were diagnosed and treated in other hospitals but have stopped glucocorticoid/immunosuppressive therapy for more than 3 months; 5. Agree to participate in this study and sign the informed consent form. Exclusion Criteria: 1. concomitant liver diseases: hepatotropic viral hepatitis (A, B, C, D, and E) and non-hepatotropic viral hepatitis (cytomegalovirus and Epstein-Barr virus (EBV) infection); 2. concomitant with drug-induced liver injury, primary biliary cholangitis, primary sclerosing cholangitis, alcoholic liver disease, genetic and metabolic liver diseases; 3. bone marrow or liver transplantation; 4. incomplete baseline medical history and laboratory examination results; 5. for previously diagnosed patients, immunosuppressive therapy was discontinued less than 3 months; 6. Pregnancy or lactation; 7. patients with contraindications to glucocorticoid/immunosuppressive therapy; 8. complicated with other malignant tumors; 9. complicated with mental disorders.