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Phase III, Open-label, Study of First-line Dato-DXd in Combination With Rilvegostomig for Advanced Non-squamous NSCLC With High PD-L1 Expression (TC ≥ 50%) and Without Actionable Genomic Alterations
Sponsor: AstraZeneca
Summary
The purpose of this study is to evaluate efficacy and safety of Dato-DXd in combination with rilvegostomig or rilvegostomig monotherapy compared with pembrolizumab monotherapy as a first line therapy in participants with locally advanced or metastatic non-squamous NSCLC with high PD-L1 expression (TC ≥ 50%) and without actionable genomic alterations.
Official title: A Phase III, Randomised, Open-label, Global Study of Datopotamab Deruxtecan (Dato-DXd) in Combination With Rilvegostomig or Rilvegostomig Monotherapy Versus Pembrolizumab Monotherapy for the First-line Treatment of Participants With Locally-advanced or Metastatic Non-squamous NSCLC With High PD-L1 Expression (TC ≥ 50%) and Without Actionable Genomic Alterations (TROPION-Lung10)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
675
Start Date
2024-04-11
Completion Date
2029-12-28
Last Updated
2026-03-16
Healthy Volunteers
No
Conditions
Interventions
Datopotamab Deruxtecan
Datopotamab Deruxtecan IV (intravenous)
Rilvegostomig
Rilvegostomig IV (intravenous)
Pembrolizumab
Pembrolizumab IV (intravenous)
Locations (281)
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Anchorage, Alaska, United States
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Tucson, Arizona, United States
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Little Rock, Arkansas, United States
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Springdale, Arkansas, United States
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Anaheim, California, United States
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Beverly Hills, California, United States
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Fountain Valley, California, United States
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Newport Beach, California, United States
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Clermont, Florida, United States
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Gainesville, Florida, United States
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Miami Beach, Florida, United States
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Orange City, Florida, United States
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Orlando, Florida, United States
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Orlando, Florida, United States
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West Palm Beach, Florida, United States
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Atlanta, Georgia, United States
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Atlanta, Georgia, United States
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Atlanta, Georgia, United States
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Atlanta, Georgia, United States
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Hinsdale, Illinois, United States
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Noblesville, Indiana, United States
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Paducah, Kentucky, United States
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Annapolis, Maryland, United States
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Boston, Massachusetts, United States
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Boston, Massachusetts, United States
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Dearborn, Michigan, United States
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Farmington Hills, Michigan, United States
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Grand Rapids, Michigan, United States
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Traverse City, Michigan, United States
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Hattiesburg, Mississippi, United States
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Kansas City, Missouri, United States
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Bozeman, Montana, United States
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Grand Island, Nebraska, United States
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Omaha, Nebraska, United States
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Las Vegas, Nevada, United States
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Reno, Nevada, United States
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Voorhees Township, New Jersey, United States
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Stony Brook, New York, United States
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Greenville, North Carolina, United States
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Salisbury, North Carolina, United States
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Cincinnati, Ohio, United States
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Columbus, Ohio, United States
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Maumee, Ohio, United States
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Toledo, Ohio, United States
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Portland, Oregon, United States
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Greenville, South Carolina, United States
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Sioux Falls, South Dakota, United States
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Chattanooga, Tennessee, United States
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Knoxville, Tennessee, United States
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Fort Worth, Texas, United States
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Houston, Texas, United States
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Houston, Texas, United States
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Houston, Texas, United States
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Kingwood, Texas, United States
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Odessa, Texas, United States
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Fort Belvoir, Virginia, United States
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Leesburg, Virginia, United States
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Midlothian, Virginia, United States
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Richmond, Virginia, United States
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Tacoma, Washington, United States
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Vancouver, Washington, United States
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Wenatchee, Washington, United States
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Appleton, Wisconsin, United States
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Birtinya, Australia
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Blacktown, Australia
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Clayton, Australia
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Gosford, Australia
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Melbourne, Australia
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South Brisbane, Australia
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Wodonga, Australia
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Innsbruck, Austria
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Krems, Austria
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Linz, Austria
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Rankweil, Austria
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Vienna, Austria
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Vienna, Austria
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Wels, Austria
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Anderlecht, Belgium
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Bruges, Belgium
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Hasselt, Belgium
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La Louvière, Belgium
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Liège, Belgium
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Barretos, Brazil
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Curitiba, Brazil
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Florianópolis, Brazil
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Ipatinga, Brazil
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Natal, Brazil
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Porto Alegre, Brazil
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Rio de Janeiro, Brazil
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Santa Maria, Brazil
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São Paulo, Brazil
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Taubaté, Brazil
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Vancouver, British Columbia, Canada
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Winnipeg, Manitoba, Canada
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St. John's, Newfoundland and Labrador, Canada
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London, Ontario, Canada
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Newmarket, Ontario, Canada
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Oshawa, Ontario, Canada
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Toronto, Ontario, Canada
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Lévis, Quebec, Canada
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Montreal, Quebec, Canada
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Montreal, Quebec, Canada
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Montreal, Quebec, Canada
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Rimouski, Quebec, Canada
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Trois-Rivières, Quebec, Canada
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Saskatoon, Saskatchewan, Canada
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Chicoutimi, Canada
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Beijing, China
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Beijing, China
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Changchun, China
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Changsha, China
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Chengdu, China
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Chengdu, China
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Chongqing, China
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Fuzhou, China
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Guangzhou, China
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Hangzhou, China
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Hangzhou, China
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Hangzhou, China
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Harbin, China
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Hefei, China
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Hefei, China
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Jinan, China
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Jining, China
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Kunming, China
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Lanzhou, China
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Linhai, China
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Linyi, China
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Nanjing, China
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Nanning, China
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Nanning, China
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Shanghai, China
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Shanghai, China
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Shanghai, China
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Shenyang, China
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Taiyuan, China
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Tianjin, China
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Wenzhou, China
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Wuhan, China
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Wuhan, China
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Wuhan, China
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Wuhan, China
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Xi'an, China
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Yangzhou, China
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Zhengzhou, China
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Zhengzhou, China
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Berlin, Germany
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Bonn, Germany
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Düsseldorf, Germany
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Essen, Germany
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Freiburg im Breisgau, Germany
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Gauting, Germany
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Georgsmarienhütte, Germany
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Gera, Germany
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Gütersloh, Germany
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Hamburg, Germany
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Hamburg, Germany
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Heidelberg, Germany
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Kempten, Germany
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Koblenz, Germany
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Ludwigsburg, Germany
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München, Germany
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Nuremberg, Germany
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Potsdam, Germany
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Ravensburg, Germany
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Budapest, Hungary
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Gyöngyös, Hungary
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Gyöngyös - Mátraháza, Hungary
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Győr, Hungary
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Gyula, Hungary
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Kecskemét, Hungary
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Salgótarján, Hungary
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Szekszárd, Hungary
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Székesfehérvár, Hungary
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Törökbálint, Hungary
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Chennai, India
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Dwārka, India
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Jaipur, India
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Kolkata, India
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Marg Jaipur, India
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Nagpur, India
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Nashik, India
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New Delhi, India
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New Delhi, India
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Surat, India
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Thiruvananthapuram, India
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Bergamo, Italy
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Genoa, Italy
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Milan, Italy
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Milan, Italy
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Monza, Italy
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Padova, Italy
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Pavia, Italy
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Ravenna, Italy
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Roma, Italy
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Rozzano, Italy
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Bunkyō City, Japan
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Bunkyō City, Japan
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Fukuoka, Japan
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Fukuoka, Japan
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Hidaka-shi, Japan
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Hirakata-shi, Japan
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Hirosaki-shi, Japan
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Hiroshima, Japan
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Kanazawa, Japan
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Kashiwa, Japan
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Kawasaki-shi, Japan
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Kumamoto, Japan
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Matsusaka-shi, Japan
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Nagoya, Japan
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Niigata, Japan
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Okayama, Japan
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Osaka, Japan
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Osakasayama-shi, Japan
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Sagamihara-shi, Japan
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Sapporo, Japan
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Takaoka-shi, Japan
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Takatsuki-shi, Japan
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Tokushima, Japan
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Tokyo, Japan
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Utsunomiya, Japan
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Yokohama, Japan
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Olsztyn, Poland
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Poznan, Poland
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Przemyśl, Poland
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Warsaw, Poland
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Warsaw, Poland
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San Juan, Puerto Rico
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Changwon, South Korea
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Incheon, South Korea
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Seongnam-si, South Korea
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Seoul, South Korea
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Seoul, South Korea
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Suwon, South Korea
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Suwon, South Korea
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Alicante, Spain
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Barcelona, Spain
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Barcelona, Spain
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Barcelona, Spain
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Jerez de la Frontera, Spain
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Reus,Tarragona, Spain
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Salamanca, Spain
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Kaohsiung City, Taiwan
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New Taipei City, Taiwan
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Taichung, Taiwan
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Taichung, Taiwan
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Tainan, Taiwan
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Taipei, Taiwan
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Taipei, Taiwan
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Taipei, Taiwan
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Taipei, Taiwan
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Taoyuan District, Taiwan
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Bangkok, Thailand
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Hat Yai, Thailand
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Muang, Thailand
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Mueang, Thailand
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Mueang, Thailand
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Adapazarı, Turkey (Türkiye)
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Ankara, Turkey (Türkiye)
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Ankara, Turkey (Türkiye)
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Antalya, Turkey (Türkiye)
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Diyarbakır, Turkey (Türkiye)
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Istanbul, Turkey (Türkiye)
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Istanbul, Turkey (Türkiye)
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Cheltenham, United Kingdom
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Inverness, United Kingdom
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London, United Kingdom
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London, United Kingdom
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London, United Kingdom
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Preston, United Kingdom
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Truro, United Kingdom
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Da Nang, Vietnam
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Hanoi, Vietnam
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Hanoi, Vietnam
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Hà Nội, Vietnam
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Ho Chi Minh City, Vietnam
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Ho Chi Minh City, Vietnam
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Ho Chi Minh City, Vietnam
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Huế, Vietnam
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Vinh, Vietnam
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Vĩnh Yên, Vietnam