Clinical Research Directory

Inclusion Criteria: * patients with knee osteoarthritis whose inclusion criteria meet the "diagnostic criteria for arthritis" . * no drug contraindications . * aged between 45 and 75 . * committed to follow the research procedures, And cooperate with the •implementation of the whole process study . * the patient understands the relevant treatment process . * the patient has the ability to give informed consent . * The patient had not recently taken any medication that affected observation. * the subjects must meet all the inclusion criteria to be eligible to participate in the study . Exclusion Criteria: * mental illness . * patients with malignant tumors. * patients with other infectious diseases . * patients with metabolic bone disease, diabetes and hyperthyroidism. * patients who cannot actively cooperate in the treatment. * hypocalcemia.