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Pilot Study of the Human Metagenome in Metabolic Diseases
Sponsor: Sengkang General Hospital
Summary
This is a cohort study to understand the role of the human metagenome, and associated metabolites, in health and in various diseased states, in particular obesity as well as sarcopenia. Recruited participants will have their fecal, salivary, urine, serum, and in certain instances, mucosal samples taken, for metagenomic sequencing and metabolite testing. We hope to uncover various differences and signatures in the metagenome and metabolome in various diseased states, with potential future therapeutic applications in personalised medicine.
Official title: Understanding the Role of the Human Metagenome in Obesity, Metabolic Diseases, Chronic Inflammation, Sarcopenia and Sarcopenic Obesity - a Pilot Study
Key Details
Gender
All
Age Range
21 Years - 99 Years
Study Type
OBSERVATIONAL
Enrollment
600
Start Date
2023-08-14
Completion Date
2027-12-31
Last Updated
2025-05-15
Healthy Volunteers
Yes
Interventions
No specific intervention
Patient will undergo their routine clinical treatment for their related clinical condition (eg. anti-obesity or bariatric intervention for obese group; muscle strengthening interventions or necessary treatment for their concomitant medical condition for the sarcopenia group). Follow-up testing will include repeat assessment of the subjects metagenome and metabolome over time, and after intervention Control subjects will have no interventions performed as well.
Locations (1)
Sengkang General Hospital
Singapore, Singapore