Clinical Research Directory

Inclusion Criteria: 1. Aged 18 to 70 years. 2. Patients diagnosed with IRAP: 1. Previously experienced 2 or more distinct episodes of acute pancreatitis (AP) with complete resolution between each episode, and absence of irreversible structural and functional changes in pancreas. The diagnosis of AP is based on the Atlanta criteria and is documented in the medical record. 2. The etiology of RAP remains undetermined after routine clinical investigations, including history, laboratory examination, imaging examination (CT, MRI/MRCP, EUS). Patients who still have AP episodes after elimination of the etiology also be included. 3. At least 1 episode of AP one year prior to enrollment. 4. Consent to participate in the study and sign the informed consent form. Exclusion Criteria: 1. Prior sphincter intervention. 2. Not recovered from prior AP attack. 3. Prior pancreatic surgery. 4. Contraindications to ERCP. 5. Major mental illness or serious health problems that are not suitable for participation in the study. 6. Pregnancy or plan for pregnancy within 12 months of enrollment. 7. Other conditions that inappropriate to participant in the study.