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Precise Evaluation Criteria for Histological Regression of NASH Fibrosis
Sponsor: Beijing Friendship Hospital
Summary
It is an observational study of NASH patients with a calculated sample size of 220. Liver biopsy-proven NASH fibrosis with stage F2-F4 will be recruited in this study. A second biopsy will be performed after clinical trials or 1-3 years of lifestyle intervention. Patients will be followed up at baseline and every six months with h-CRP, liver function tests, fasting blood glucose, fasting insulin, ferritin, liver ultrasonography, and liver stiffness measurements.
Official title: Establishment of Precise Evaluation Criteria for Histological Regression of NASH-related Liver Fibrosis
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
OBSERVATIONAL
Enrollment
220
Start Date
2024-06-15
Completion Date
2027-04-01
Last Updated
2024-05-29
Healthy Volunteers
No
Conditions
Interventions
lifestyle intervention
Dietary recommendations should consider energy restriction and exclusion of MAFLD-mediating components (processed food, food and beverages high in added fructose). A Mediterranean type diet is advisable. Both aerobic exercise and resistance training effectively reduce liver fat and should be tailored based on patient preferences to ensure long-term adherence.