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Screening for AL Amyloidosis in Smoldering Multiple Myeloma
Sponsor: Tufts Medical Center
Summary
In this multicenter study, we will recruit 400 patients 40 years of age or older at 15 centers with a diagnosis of smoldering multiple myeloma (SMM), a group of patients for whom standard of care is observation not treatment. The main goal of this study is to screen for the diagnosis of light-chain amyloidosis (AL) before the onset of symptomatic disease and to develop a training set for a likelihood algorithm.
Key Details
Gender
All
Age Range
40 Years - Any
Study Type
OBSERVATIONAL
Enrollment
400
Start Date
2024-05-01
Completion Date
2029-02-27
Last Updated
2025-08-06
Healthy Volunteers
No
Conditions
Locations (13)
University of Alabama Hospital
Birmingham, Alabama, United States
Cedars-Sinai Medical Center
Los Angeles, California, United States
University of California, San Francisco
San Francisco, California, United States
Cleveland Clinic Florida, Weston Hospital
Weston, Florida, United States
Tufts Medical Center
Boston, Massachusetts, United States
Columbia University Irving Medical Center
New York, New York, United States
Memorial Sloan Kettering Cancer Center
New York, New York, United States
Atrium Health Levine Cancer Institute
Charlotte, North Carolina, United States
UNC Lineberger Comprehensive Cancer Center
Durham, North Carolina, United States
The Ohio State University Comprehensive Cancer Center
Columbus, Ohio, United States
UT Southwestern, Harold C. Simmons Comprehensive Cancer Center
Dallas, Texas, United States
University of Utah, Huntsman Cancer Hospital
Salt Lake City, Utah, United States
VCU Medical Center
Richmond, Virginia, United States