Clinical Research Directory

Inclusion Criteria: Consecutive adult patients (≥ 18 years) with septic shock defined by Sepsis-3 consensus criteria. (ie septic shock defined as suspected or confirmed infection, hyperlactatemia and noradrenaline requirement, after a fluid load of at least 1000mL in 1 hour) Exclusion Criteria: Any of the following criteria preclude participation to the trial: 1. More than 4 hours since septic shock diagnosis, 2. Surgery or acute renal replacement therapy anticipated to start during the 6h intervention period 3. Active bleeding, 4. Child B-C Cirrhosis 5. Underlying disease process with a life expectancy \<90 days 6. Attending clinician deems aggressive resuscitation unsuitable 7. Refractory shock (high risk of death within 24h) 8. Pregnancy 9. Concomitant severe acute respiratory distress syndrome 10. Capillary refill time cannot be accurately assessed