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Mechanism Study of Ventilator-Induced Lung Injury in Elderly People.
Sponsor: Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Summary
1. We collect lung tissues from patients with different ages and confirm that KLK8 expression is positively correlated with age. 2. We collect peripheral blood from patients with different ages and duration of mechanical ventilation to explore the correlation between the degree of endothelial/epithelial damage, age and duration of mechanical ventilation.
Official title: Mechanism Study Under the Role of Tissue Kallikrein-related Peptidase 8 (KLK8)-Induced Senescence of Pulmonary Vascular Endothelial Cells in Ventilator-induced Lung Injury in Elderly People.
Key Details
Gender
All
Age Range
Any - Any
Study Type
OBSERVATIONAL
Enrollment
1000
Start Date
2023-06-01
Completion Date
2027-06-30
Last Updated
2024-04-16
Healthy Volunteers
No
Conditions
Interventions
mechanical ventilation
Mechanical ventilation is machine-delivered flow of gases to both oxygenate and ventilate a patient who is unable to maintain physiological gas exchange.
Locations (1)
Shanghai Xinhua hospital
Shanghai, China