Clinical Research Directory

Inclusion Criteria: * Male or female aged ≥ 30 years and ≤ 70 years old. * Body Mass Index included between 18 Kg/m2 and 35 Kg/m2 * Total cholesterolemia between 200 and 280 mg/dL and/or LDL-Cholesterol between 130 mg/dL and 190 mg/dL. * TG\<400 mg/dL. * Subjects who, according to the SCORE charts, have a low or moderate cardiovascular risk (defined as a total cardiovascular risk \< 5%) and for whom, according to ESC/EAS guidelines 2012, the intervention strategy does not require a pharmacological lipid-lowering intervention. * Subjects who have the capability to communicate, to make themselves understood, and to comply with the study's requirements. * Subjects agree to participate in the study and having dated and signed the informed consent form. Exclusion Criteria: * Assumption of lipid lowering drugs or dietary supplements, or drugs potentially affecting the lipid metabolism; * Assumption of any kind of drug treatment non-stabilized for at least 3 months; * Known current thyroid, gastrointestinal or hepatobiliary diseases (including liver transaminases ≥3ULN), as well as any muscular disorders (even subclinical, including serum CPK ≥3ULN); * Current or previous alcohol abuse; * Pregnancy and Breastfeeding * Known previous intolerance to red yeast rice * History or clinical evidence of any significant concomitant disease that could compromise the safety of the subject or the possibility of completing the study; * Any medical or surgical condition that would limit the patient adhesion to the study protocol.