Clinical Research Directory

Inclusion Criteria: * Are males and females at least 21- 70 years of age (inclusive) * Capable of giving informed consent * Are of any race or ethnicity * Can communicate in English * Females may be on oral contraceptives but will be excluded if they are pregnant or lactating * Healthy Status as defined by the absence of evidence of any active or chronic disease as determined by the following: * a detailed medical history * complete physical examination (including vital signs) * a blood pressure that is within a safe range (\<150/100mmHg) Exclusion Criteria: * \< 21 years of age or \> 70 years of age * Pregnant or nursing woman * Prisoners or institutionalized individuals unable to consent * Decisional impairment * Not able to communicate in English. * Current smoker * Have any clinically relevant history or the presence of metabolic (e.g., diabetes), respiratory, renal, hepatic, gastrointestinal, hematological, lymphatic, neurological, cardiovascular, or other disease or diseases that, in the opinion of the research team, exclude the subject from participation. * Presenting with a resting blood pressure of 150/100 or higher * Taking any medications that affect vascular control or autonomic function (e.g. beta blockers, ACE inhibitors, calcium channel blockers, etc.) * Taking a multivitamin with B6, a B-complex vitamin, or vitamin B-6 at baseline, with a history of Parkinson's disease, and taking levodopa * Known allergy or hypersensitivity to Vitamin B6 * Opioid Use Disorder or on opioid therapy * Subject has a recent drug or alcohol abuse history (less than 6 months) or is currently using or abusing excessive alcohol or drugs. Excessive alcohol will be defined as greater than 14 drinks per week. Use of recreational drugs in the past 6 months is also an exclusion.