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Mechanisms of Acute Kidney Injury in Severe Infections
Sponsor: Uppsala University Hospital
Summary
Renal perfusion and neutrophil-mediated inflammation will be assessed in the kidney in sepsis patients with acute kidney injury using positron emission tomography. For marked water will be used for renal perfusion and a newly developed PET tracer molecule (11C-GW457427) with specific binding to neutrophil elastase which provides a measure of the amount of infiltrating neutrophils in the renal parenchyma for inflammation. The study is performed in a PET-CT camera where anatomical imaging takes place at the same time as the PET examinations.
Key Details
Gender
All
Age Range
30 Years - Any
Study Type
OBSERVATIONAL
Enrollment
15
Start Date
2024-05-01
Completion Date
2026-06-30
Last Updated
2024-12-06
Healthy Volunteers
Yes
Interventions
Positron emission tomography (PET)
Assessment of blood flow with marked water and assessment of neutrophil presence with neutrophil elastase tracer + CT
Locations (1)
Uppsala university hospital
Uppsala, Sweden