Clinical Research Directory

Inclusion Criteria: 1. patients meet the diagnostic criteria for end-stage renal disease; 2. indications that the patient may be experiencing signs and/or symptoms of heart failure, and based on the serum N-terminal pro-brain natriuretic peptide level of greater than 11,215. 2 ng/L; 3. patients may require prolonged intermittent renal replacement therapy due to volume overload; 4. patients ≥18 yo and ≤80 yo; 5. either the patient or a family member signs the informed consent; 6. patients will undergo at least two sessions of prolonged hemodialysis. Exclusion Criteria: 1. history of malignancy or psychiatric disease; 2. patients with a history of congenital heart disease or hypertrophic cardiomyopathy; 3. coagulation abnormalities, intracranial, visceral or gastrointestinal bleeding in the past 3 months, or contraindications to heparin anticoagulation; 4. The duration of prolonged hemodialysis \<8 hours; 5. Ultrasound unable to monitor the inferior vena cava, or can't access the date; 6. Pregnancy; 7. Patients with severe respiratory failure; 8. Patients with combined severe infections, such as patients with sepsis; 9. Presence of pre-dialysis hypotension: systolic blood pressure \<90 mmHg; 10. other conditions deemed ineligible by physicians.