Clinical Research Directory

Inclusion Criteria: 1. Meet the International League Against Epilepsy 2017 diagnostic criteria for epilepsy; and the patient's seizures can be clearly classified as partial seizures according to the seizure classification proposed by the International League Against Epilepsy, including simple partial seizures, complex partial seizures, and secondary generalised seizures; 2. Be greater than or equal to 2 years of age; 3. Have been on antiepileptic medication, and during the 4-week period of the retrospective baseline period, the patient did not medication adjustments and had at least 2 seizures greater than or equal to 2 seizures per 4-week period; 4. The patient demonstrated good compliance and was able to complete the scale assessment and record the epilepsy diary on his/her own or with the assistance of a parent; 5. The informed consent form was signed and dated by the patient or a parent or legal guardian. Exclusion Criteria: 1. Patients who are allergic to zonisamide ; 2. CT or MRI suggestive of progressive intracranial tumours; 3. Severe mental retardation or severe psychiatric disorders; 4. Patients suffering from serious underlying diseases that can affect brain function, such as heart disease, liver disease, renal disease, haematological disorders, malignant tumours, and patients who are immunocompromised; 5. Ultrasound suggestive of renal stones 6) Pregnant or breastfeeding