Clinical Research Directory

Inclusion Criteria: 1. Age ≥ 18 years. 2. NYHA ≥ 2 and/or syncope and/or angina. 3. Symptomatic severe calcified aortic stenosis with AVA \< 1 cm2 AND peak velocity \> 4 m/s or mean gradient \> 40 mmHg or DVI \< 0.25'. 4. Patient judged by the Heart Team as indicated for TAVI. 5. Anatomical suitability for transfemoral-TAVI with Navitor, based on MSCT assessment. 6. Estimated life-expectancy \> 1 year. Exclusion Criteria: 1. Age \< 18 years 2. Asymptomatic patients 3. Estimated life expectancy \< 1 year 4. Pure aortic regurgitation. 5. LVEF \< 20% 6. No baseline MSCT evaluation. 7. Unsuitable aortic root anatomy for Navitor. 8. Unsuitable peripheral vasculature for transfemoral Navitor. 9. Type 2 bicuspid aortic valve 10. Excessive leaflet calcifications 11. Moderate or severe raphe calcifications 12. Severe LVOT calcifications 13. Perimeter-derived annular dimension exceeding IFU recommendation 14. Dilated ascending aorta \>45 mm