Clinical Research Directory

Inclusion Criteria: * Diagnosis of type 2 diabetes, * Generalized microvascular dysfunction, i.e. * eGFR 30-60 mL/min/1.73m2, and/or * Microalbuminuria albumin-creatinine ratio 3-30 mg/mmol, and/or * Retinopathy (not proliferative), and/or * Neuropathy (any). Exclusion Criteria: * Uncontrolled diabetes (i.e., hypoglycaemia \>2 times/week and/or unstable HbA1c \>9%), * Use of \>12 Units long-acting insulin per day, * Use of short-acting insulin, * Intraocular pressure ≥30 mmHg, * History of glaucoma, * Diagnosis of proliferative diabetic retinopathy, * Diagnosis of diabetic macula edema, * Albumine-creatinine ratio \>30 mg/mmol, * eGFR \<30 mL/min/1.73m2, * Diagnosis of epilepsy, * Active cardiovascular disease, * Alcohol usage \>4 U/day, * Drugs abuse, * Use of systemic glucocorticosteroids, * Higher grade hypertension * Diagnosis of inflammatory disease, * Use of an investigational product within the previous month, * Unstable body weight, * Pregnancy or lactation, * Change in use of oral contraceptives or IUD, * Unwillingness to give up being a blood donor (or having donated blood) from 8 weeks prior to the start of the study to end of study, * Insufficient knowledge of the Dutch language, * Inability to provide written informed consent.