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Pain After Removal of Mandibular Third Molars With or Without Advanced Platelet-rich Fibrin
Sponsor: Aalborg University Hospital
Summary
Pain is the most common complication following surgical removal of an impacted mandibular third molar. Several risk factors may increase the intensity and duration of pain following removal of mandibular third molars. Acute postoperative pain can transcript into postoperative chronic pain without an explainable reason or a specific risk factor. The use of advanced platelet-rich fibrin in the extraction socket following surgical removal of mandibular third molar have diminished the intensity and duration of acute postoperative pain and facilitated improved wound healing. The objective of the present study is therefore to identified specific risk factors and predictors for developing postoperative chronic pain following surgical removal of mandibular third molars with or without advanced platelet-rich fibrin applied in the extraction socket using epigenetic modulation.
Official title: Assessment of Chronic Pain Predictors Following Surgical Removal of Mandibular Third Molars
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
80
Start Date
2024-01-10
Completion Date
2025-12-01
Last Updated
2024-04-22
Healthy Volunteers
Yes
Conditions
Interventions
Advanced platelet-rich fibrin in the ekstraction socket
Advanced platelet-rich fibrin is a centrifuged fibrin matrix composed of concentrated growth factors, platelet cytokines, and blood cells, which possesses the ability to stimulate wound healing and tissue regeneration. Advanced platelet-rich fibrin is manufacturing from a blood sample.
Locations (1)
Department of Oral and Maxillofacial surgery, Aalborg University Hospital
Aalborg, North Denmark, Denmark