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Effect of Propofol vs. Sevoflurane on Erections During Narcosis In Transurethral Surgery
Sponsor: Etienne Xavier Keller
Summary
Penile erection is an unwanted event in transurethral (through the urethra) surgeries, which may be associated with adverse outcomes such as impaired access, prolonged operation time, the need to abort the operation, or the necessity for ancillary measures to achieve penile flaccidity, such as the injection of certain medications directly into the penis. To reduce greenhouse gas emissions, the primary use of propofol instead of gaseous agents is being recommended for general anesthesia. Whether propofol may be associated with an increased or decreased rate of unwanted intraoperative penile erection compared to other anesthetic agents is not known. More generally, there are no high-quality studies available to evaluate the impact of the type of general anesthesia on the risk of unwanted penile erections during surgery. This study aims to determine whether general anesthesia with propofol is more likely to cause intraoperative erections compared to sevoflurane during transurethral operations.
Official title: Prospective, Randomized-Controlled Study of the Effect of Propofol vs. Sevoflurane on Erections During Narcosis in Transurethral Surgery
Key Details
Gender
MALE
Age Range
18 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
200
Start Date
2024-02-01
Completion Date
2026-12-01
Last Updated
2024-04-22
Healthy Volunteers
No
Conditions
Interventions
General Anesthesia: Propofol
Transurethral surgery at the Department of Urology (University Hospital Zurich) performed under study arm-specific anesthesia. Propofol will be administered intravenously using the target-controlled infusion algorithm with effect site concentrations between 1.5-4.0 µg/ml necessary.
General Anesthesia: Sevoflurane
Transurethral surgery at the Department of Urology (University Hospital Zurich) performed under study arm-specific anesthesia. Sevoflurane will be given in gaseous form via the endotracheal tube in concentrations between 1.5-2.5% Vol.
Locations (1)
University Hospital Zurich
Zurich, Switzerland