Clinical Research Directory

Inclusion Criteria: 1. Age range from 18 to 70 years old; 2. Expected survival time\>12 weeks; 3. Diagnosed as multiple myeloma through physical examination, pathological examination, laboratory examination, and imaging; 4. Difficult to treat multiple myeloma patients; 5. Patients with recurrent multiple myeloma; 6. ALT, AST\<3 times normal; Bilirubin\<2.0mg/dl; 7. Quality of Life Score (KPS)\>50%; 8. The patient has no serious diseases such as heart, liver, or kidney; 9. Recurrence or no remission of the disease after hematopoietic stem cell transplantation or cellular immunotherapy; 10. Inappropriate conditions for stem cell transplantation or abandonment of transplantation due to limitations in conditions; 11. Blood can be taken intravenously without any other contraindications for leukocyte removal surgery; 12. Can understand and voluntarily sign a written informed consent form. Exclusion Criteria: 1. Pregnant or lactating women, or women with pregnancy plans within six months; 2. Infectious diseases (such as HIV, active tuberculosis, etc.); 3. Active hepatitis B or hepatitis C infection; 4. Feasibility assessment screening proves that the transfection of targeted lymphocytes is less than 10% or the amplification is insufficient (\<5-fold) under the co stimulation of CD3/CD28; 5. Abnormal vital signs and inability to cooperate with the examination; 6. Individuals with mental or psychological disorders who cannot cooperate with treatment and efficacy evaluation; 7. Highly allergic constitution or a history of severe allergies, especially those who are allergic to IL-2; 8. Subjects with systemic or severe local infections requiring anti infection treatment; 9. Subjects with severe autoimmune diseases; 10. The doctor believes that there are other reasons why patients cannot be included in treatment.