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Non-steroidal Anti-inflammatory in Cardiac Surgery
Sponsor: Centre Hospitalier Universitaire, Amiens
Summary
Non-steroidal anti-inflammatory drugs (NSAID) are part the multimodal strategy in pain management after surgery. However, major concerns are raised in cardiac surgery given the potential side effects of NSAID with more bleeding and acute kidney injury. The investigators hypothesized that NSAID are safe in the early postoperative course after cardiac surgery with respect to contraindication.
Official title: Effect of Non-steroidal Anti-inflammatory Drugs in Pain Management After Cardiac Surgery
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
238
Start Date
2024-03-27
Completion Date
2027-07
Last Updated
2025-07-23
Healthy Volunteers
No
Conditions
Interventions
pain management
o Pain management in both arms Intraoperative time: intravenous ketamine 0.5 mg kg-1, intravenous dexamethasone 8 mg Postoperative time: paracetamol 1 g every 6 hours a day, nefopam 20 every 8 hours a day, patient control analgesia with morphine or oxycontin
ketoprofen
Ketoprofen 100 mg twice a day, during 48 after surgery, intravenous administration
PLacebo
Placebo twice a day, during 48 h after surgery, intravenous administration
Locations (1)
CHU Amiens Picardie
Amiens, France