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Biomarkers and Molecular Mechanism Study of Hepatocellular Carcinoma After Radical Resection and Conversion Therapy
Sponsor: Shanghai Zhongshan Hospital
Summary
Blood samples will be tested to identify circulating tumor DNA and plasma protein levels to potentially improve prediction of long term prognosis and guide treatment options of patients with hepatocellular carcinoma underwent surgical resection.
Key Details
Gender
All
Age Range
Any - Any
Study Type
OBSERVATIONAL
Enrollment
240
Start Date
2024-05-15
Completion Date
2026-05-20
Last Updated
2025-03-26
Healthy Volunteers
No
Conditions
Interventions
ctDNA monitoring
The ctDNA level will be measured using tumor-informed (Signatera platform) and tumor-naived (fragmentomes measurement) assay.
Plasma proteomic analysis
plasma protein level will be measured via Proximity Extension Assay and LC-MS based proteomic analysis
Locations (1)
Zhongshan Hospital Fudan University
Shanghai, China