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The PRO-FUTURE Project
Sponsor: University of Campania Luigi Vanvitelli
Summary
The goal of this observational study is to learn about specific biomarkers of unilateral ureteropelvic junction obstruction (UPJO) in children undergoing surgical intervention for unilateral UPJO compared with controls. The main question it aims to answer are: * Are Urinary single-cell and extracellular vesicles (EVs) screening useful to stage the intrarenal injury and repair processes in UPJO babies? * Do babies with unilateral UPJO have a whole blood gene expression profiling (WBGEP) allowing an accurate unilateral UPJO diagnosis?
Official title: PRecocious biOmarkers oF Unilateral ureTero-pelvic jUnction obstRuction in childrEn
Key Details
Gender
All
Age Range
1 Day - 5 Years
Study Type
OBSERVATIONAL
Enrollment
85
Start Date
2024-01-30
Completion Date
2028-01-30
Last Updated
2024-04-30
Healthy Volunteers
No
Interventions
Identification of Diagnostic Biomarkers
Urinary single-cell and EVs screening to stage the intrarenal injury and repair processes in UPJO babies and identification of the whole blood gene expression profiling of babies with unilateral UPJO. Data deriving from patients with unilateral UPJO will be compared with data deriving from controls.
Locations (5)
Univeristà degli Studi della Campania Luigi Vanvitelli
Naples, Campania, Italy
Department of Clinical Sciences and Community Health, University of Milano
Milan, Italy
Fondazione IRCCS Ca' Granda-Ospedale Maggiore Policlinico
Milan, Italy
Obstetrics and Gynecology Unit, University of Modena and Reggio Emilia
Modena, Italy
AORN Santobono-Pausilipon
Naples, Italy